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Oxaliplatin affects the expression level and/or function of ion channels and induces excessive neuronal excitation, oxidative stress, and neurodegeneration through multiple mechanisms (Figure 1)

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Malaguarnera et al (42) demonstrated that in patients with minimal hepatic encephalopathy, acetyl-L-carnitine improved the quality of life by reducing serum albumin levels

In sum, long-term infertility is associated with a modified methylome in euploid blastocysts with specific concentration on regulation pertaining to genomic imprinting, which is compared to aided reproductive technologies alone (Reference Denomme, Haywood and McCallie37)