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During infection, immune cells produce ROS to combat pathogens

doi: 10.1007/s00787-019-01333-5 146 SharghiSFlunkertSDaurerMRablRChagnaudBPLeopoldoMet al

These authors also established that the combination of APR-246 with different compounds and strategies inducing ferroptosis (pharmacological compounds, or genetic inactivation of SLC7A11 or GPX4) had a synergistic effect on the promotion of AML cell death, both in vitro and in vivo

The detrimental health impacts of these disruptions include impaired glucose metabolism, alterations in endocrine and immune functions, elevated blood pressure, and heightened levels of inflammatory markers associated with shift work [18-24]