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Kampatsikas, I., Bijelic, A., Pretzler, M

Oxidative stress: major executioner in disease pathology, role in sperm DNA damage and preventive strategies

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In brief, inhibition of TrxR augments the susceptibility of tumor cells to oxidative stress, bolsters the selective eradication of cancerous cells, and instigates the cascade of apoptosis, which has received widespread attention in recent years making TrxR a potential target for cancer therapy (191, 192)