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When adjusting, change only one variable at a time

Passini MA, Dodge JC, Bu J, Yang W, Zhao Q, Sondhi D, Hackett NR, Kaminsky SM, Mao Q, Shihabuddin LS, Cheng SH, Sleat DE, Stewart GR, Davidson BL, Lobel P, Crystal RG (2006) Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis

Thyroid disease, medication effects and sleep apnoea do not respond to lipotropics

Methionine and choline help support overall liver health, not just fat metabolism

We would need large, placebo-controlled trials with proper imaging and functional outcome measures to confirm these effects in humans