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Additionally, research has explored NAD+'s role in acute neurological injuries such as stroke and traumatic brain injury using experimental models, with studies suggesting that rapid NAD+ depletion following brain injury contributes to neuronal death and that NAD+ restoration may be neuroprotective in research models

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10.1093/hmg/ddl068 Summary Keywords docosahexaenoic acid, hippocampal cells, glutathione peroxidase 4, phospholipid-hydroperoxide glutathione peroxidase, transcriptional regulation, intron retention, neuroprotection Citation Casaas-Snchez V, Prez JA, Fabelo N, Quinto-Alemany D and Daz ML (2015) Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase ( Gpx4 ) gene expression to ensure self-protection from oxidative damage in hippocampal cells