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Many of the available findings come from laboratory or animal studies, and those results cannot automatically be applied to people

5 Rather than affecting drug concentration (as with pharmacokinetic interactions), the net effect of the agent(s) on physiological functions may be enhanced or reduced by competitive binding or blocking of receptor sites

Hup M, Rivire P, Nancey S, et al

The procedure can be total or partial, depending on the condition being treated

Second, the short-term nature of the study, with two weeks devoted to each dosing schedule for each patient, allows for examination of short-term parameters, such as sleep and wakefulness, but not longer-term outcomes such as IGF-I levels, growth rates, or bone maturation