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Subsequent membrane depolarization triggers the opening of voltagegated calcium channels, leading to a localized influx of Ca 2+ , The binding of calcium to synaptotagmin serves as the molecular trigger for the rapid fusion of synaptic vesicles and exocytotic release of dopamine into the synaptic cleft [193]

Finally, the potential generalisability of the findings to other population needs to be interpreted with caution as our data represent only a surgical case series from a single centre

SPDEF is responsible for triggering goblet cell metaplasia where airway epithelial multipotent basal, club, and ciliated cells are differentiated into mucus-secreting goblet cells and trigger a surge in mucus production (196, 197)