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The presence of CD206+/CD163+ M2 macrophages at the site of renal injury is associated with the severity of fibrosis ( Injured renal epithelial cells produce DAMPs and pathogen-associated molecular patterns (PAMPs) ( Interestingly, increased migration of macrophages around tubular epithelial cells that have been damaged by lipotoxicity has been described as a hallmark of diabetic nephropathy ( Increased expression of CD74 has been found in podocytes and parietal epithelial cells ( Figure 2 illustrates the sequential role of macrophages in the progression of CKD, emphasizing key stages, cytokine interactions, and molecular pathways

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