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FACS confirmed that the results are consistent with the observation (Figure 3C)

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Endocrine Rev 39 (6):9901028 Crevar-Saka M, Vuji Z, Kotur-Stevuljevi J, Ivanievi J, Jeli-Ivanovi Z, Milenkovi M, Markelic M, Vuji Z (2016) Effects of atorvastatin and artichoke leaf tincture on oxidative stress in hypercholesterolemic rats

The theoretical concern about Wnt pathway activation and cell proliferation, while not demonstrated to cause problems with topical PTD-DBM, warrants caution in these populations