BRAF V600E co-occurs with a similar set of alterations in pediatric and adult tumors, and both patient groups can benefit from BRAF-targeted therapy ( In non-CNS solid cancers, BRAF V600E is frequently detected in malignant melanoma, hairy cell leukemia, colorectal carcinoma, and papillary thyroid carcinoma, as well as ovarian and lung tumors ( V600 mutation ( V600E -mutated melanoma were more likely to have CNS involvement than those with BRAF wild-type melanoma ( V600E expression cooperates with Pten tumor suppressor loss to generate metastatic melanoma without CNS involvement ( V600E in Cdkn2a Null mice generates melanomas without metastasis, but AKT1 activation promotes development of CNS metastases in this model ( In conclusion, BRAF V600E expression is a driver mutation of CNS tumors that occur in various neuroanatomic locations and exhibit a wide range of age at presentation
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( B ) Flow cytometry of CHH stained APEX2 expressing HeLa cells treated with substrate (HPI, 1 mM), H 2 O 2 (100 M, repeated hourly for 5 h) or with the combination of substrate and H 2 O 2
(2024) 102:aos.15821
Koeglsperger et al., 2023)
