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10.1016/j.neures.2008.10.009 34 ChengY.HeG.MuX.ZhangT.LiX.HuJ.et al (2008)

In contrast, RelA/p65, a member of the NF-B family, suppresses PGC1-driven PDK4 transcription, thereby increasing PDHC activity and maintaining pyruvate flux into the TCA cycle

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Treatment of MTHFR also needs to be directed towards toxin control if the body is strong enough to handle it

This diagnostic aspect helps in identifying the location, extent, and characteristics of the disease [354,355]