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These authors also discovered that metformin enhanced the anti-hepatoma effect of tubulin depolymerization inhibitor epothilone A by enhancing its pro-apoptotic effect and increasing levels of NF-B (94)

If risk factors such as silica and asbestos cannot be eliminated promptly, acute inflammation may progress into chronic inflammation, resulting in aberrant wound healing responses and fibrosis [30]

PTMs targeting vascular transcription factors Metabolites represent a key source of molecules involved in protein PTMs and fine-tune protein functions in response to nutrient status and external cues