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Other intestinal proteases implicated in IBD In addition to metalloproteinases, a wide range of intestinal proteases, such as serine- (Neutrophil elastases (NE), tryptases, cathepsin G), cysteine- (Caspases), and luminal- (bacterial-derived) proteases, contribute to increased proteolytic activity and consequent barrier leakiness [12]

95 Recently, it has been demonstrated that PYY 3-36 is also produced by neurons of the paraventricular nucleus (PVN), ARC, and supraoptic nuclei of the human hypothalamus

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HDC, high density collagen