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It results in steric clash between the aligned ubiquitin (Ub Align ) and the UT3c subdomain ( Fig

Aging is a natural, inevitable process that affects all parts of the body

Drugs like allopurinol, sulfonamides, pyrazinamide, phenytoin, isoniazid, penicillin and quinidine have been found to cause such injury [4,8]

GI symptoms, including excessive salivation, dysphagia, constipation, esophageal motility disorders, and gastric abnormalities, occur many years before the appearance of motor symptoms and may be associated with an increased risk of developing PD [112]