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Corticosteroid and NAC nasal douching significantly reduced symptom severity more than two-fold, resolved mucosal edema, and restored mucociliary function in recurrent acute rhinosinusitis patients compared to steroid with ambroxol, leading to better long-term satisfaction (121)

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International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) Challenges and opportunities in IBD clinical trial design