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101, 1505215057.10.1073/pnas.0403277101 21 HicksL

Given the central role of the JAK/STAT pathway in the pathogenesis of AA, it represents a therapeutic target that has opened new avenues for understanding and managing the disease.5 Currently, two therapies have been approved for severe AA: baricitinib, an oral JAK1/2 inhibitor, approved for the treatment of adults (18 years),9 and ritlecitinib, an oral dual selective inhibitor of the JAK3/TEC kinase family, approved for patients aged 12 years

GSTO1 labelling was inhibited up to 6 h and then recovered completely by 24 h (Fig

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