doi: 10.1016/j.cell.2013.12.010 182 ZhuSZhangQSunXZehHJ3rdLotzeMTKangRet al
Hahn, MD, PhD Dana-Farber Cancer Institute EDUCATIONAL TITLES William Rosenberg Professor, Medicine, Harvard Medical School Professor of Medicine, Medical Oncology, Dana-Farber Cancer Institute Chief Operating Officer, Medical Oncology, Dana-Farber Cancer Institute HCC PROGRAM AFFILIATION Cancer Cell Biology, Member Prostate Cancer, Member Research Abstract Functional genomics and human cell transformation My work as a physician-scientist involves both the care of cancer patients and biomedical research directed toward a greater understanding of the mechanisms involved in malignant transformation
IR may be linked to endothelial dysfunction by the number of mechanisms such as disturbance in subcellular signaling pathway and PI-3-kinase/Akt pathway.[18] ACANTHOSIS NIGRICANS AND ADIPOKINES Acanthosis nigricans patients have hyperinsulinemia and may be at greater risk of atherosclerotic cardiovascular disease.[19] The commonest underlying cause of IR is excess abdominal adipose tissue which releases increased amounts of free fatty acids which directly affect insulin signaling, diminish glucose uptake in muscle, drive exaggerated triglyceride synthesis and induce gluconeogenesis in liver
Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1
Kou et al., 2023)
