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Bloisi W, Colombo I, Garavaglia B, Giardini R, Finocchiaro G, Didonato S

High baseline AR abundance and activity was required for growth inhibition by SPA, as inducible shRNA-mediated knock-down of AR in LNCaP cells (Figure 1B) resulted in resistance to SPA (Figure 1C) and rescued clonogenic survival following SPA treatment (Supplemental Figure 2)

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Valproic Acid Oral Solution - Clinical Pharmacology 12.1 Valproic Acid Oral Solution Mechanism of Action Valproic acid dissociates to the valproate ion in the gastrointestinal tract