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Numerous studies have demonstrated that mtDNA can strongly induce inflammation via cGAS and STING1, particularly when apoptotic caspase activation is limited (165)

Low B12 can cause tiredness, nerve problems, depression, and increased heart disease risk from high homocysteine

Clinical Studies 14.1 Healing of EE in Adults The healing rates of NEXIUM delayed-release capsules 40 mg, NEXIUM delayed-release capsules 20 mg, and omeprazole delayed-release capsules 20 mg (the approved dose for this indication) once daily were evaluated in adult patients with endoscopically diagnosed EE in four multicenter, double-blind, randomized studies