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It has also been reported that VEGF alters the expression and distribution of TJs proteins, leading to BBB hyperpermeability in hypoxia and autoimmune encephalomyelitis (Zhang et al., 2000)

Manganese deficiency may play a significant role in carcinogenesis by activating the p53 protein, which triggers apoptosis in cells through mitochondrial pathways (Garrick et al., 2003[156])