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The exact mechanism of resistance offered and the systemic implications of glutathione supplementation need to be sought out but most of the reactions are supposed to be a manifestation of its antioxidative property

Aline B

Most studies have focused on oral or injectable glutathione, with fewer examining topical applications specifically

These compounds have high solubility in water owing to the presence of OH substituent(s)

This review critically evaluates current and emerging therapeutic strategies, including locoregional treatments, systemic chemotherapy, and combination therapies, alongside innovative approaches such as oncolytic viral therapy, EV-based therapies, non-coding RNA (ncRNA) interventions, electric field therapy, and precision medicine advancements (Fig