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1 Indeed, neurologist and lead investigator in the field, Claudia Sommer, M.D

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For instance, individuals often display mitochondrial dysfunction, oxidative stress, and disturbances in methylation pathways

In detail, early transcranial magnetic stimulation studies in SMA types 2 and 3, employing threshold-tracking techniques and normalization of muscle responses to peripheral stimulation, quantified and showed preserved motor cortical output alongside disproportionately increased muscle responses to cortical stimulation, suggesting compensatory neuroplasticity [13]