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Most patients notice early changes within 4 to 8 weeks, with more meaningful improvements in pain and function between 3 and 6 months

Tirzepatide (Zepbound), a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, received FDA approval for chronic weight management in November 2023

Knorke, H., Li, H., Warneke, J., Liu, Z.-F

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Microdosing: when less than 50 units might be the right approach Not everyone follows the standard escalation schedule