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Moreover, glial cells readily populate brain regions with active neurodegeneration, increasing the potential for high NO levels that can further exacerbate toxicity in surrounding cells

As this is the first study to assess such measures, the predictive value of these markers will become even more solidified as future studies are completed and similar protein concentrations can be compared on new and even larger populations from the DRC, as well as konzo affected communities in other countries of sub-Saharan Africa

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doi: 10.3389/fphys.2017.00600

attention to AMPK/Nrf2/HO-1, -Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay