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doi: 10.3390/molecules24213854 59

Researchers modeling repeat-dose experiments generally aim to reach steady-state concentrations after four to five half-lives of continuous administration

Second, previous studies have revealed that orexin neurons are modulated by IGF-1 (37), which may play an important role in the pathophysiology of insomnia

Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition

The non-24-hour sleep-wake rhythm disorder is most commonly seen in blindness, since the light-dark cycle is the most powerful cue for synchronizing the hypothalamic pacemaker to the 24-hour day (103)