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In another study, IGF-1 was shown to regulate glucose metabolism in cancer cells with the involvement of kallikrein-related peptidase 10 (KLK10) and the knockdown of KLK10 markedly inhibited glucose metabolism and PI3K/Akt/mTOR signaling activation, a process that could be reversed by IGF-1, suggesting that IGF-1 and KLK10 serve as potential targets for regulating metabolic remodeling in colon cancer (79)

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10.1146/annurev.biochem.74.082803.133518 Annu

Oxidative stress caused by iron overload further induces lipid peroxidation, destroys mitochondrial membrane and function, and causes redox imbalance

Suspecting pyroglutamic acidosis, paracetamol was discontinued, and a urinary organic acid assay was sent