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Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia

Additionally, genetic and epigenetic variability among patients, resistance mechanisms, potential side effects, and the difficulties of translating preclinical findings to clinical applications further complicate the development of effective NRF2-targeted therapies

Nat Metab, 6(11):2100-2117

Gutierrez RMP, Velazquez EG (2020) Glucopyranoside flavonoids isolated from leaves of Spinacia oleracea (spinach) inhibit the formation of advanced glycation end products (AGEs) and aldose reductase activity (RLAR)