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Abstract Stromal cells have emerged as central drivers in multiple and diverse diseases, and consequently, as potential new cellular targets for the development of novel therapeutic strategies

Certain drugs such as methotrexate and trimethoprim act as folate antagonists and can cause folate deficiency by inhibiting the enzyme dihydrofolate reductase, which converts unreduced dietary folates to the biologically active tetrahydrofolates [62]

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We note that, for purposes of interpreting the statutory provisions, codification in our regulations, and discussion in our rulemakings, we use the term request in the same way as apply and application, and use the term approve in the same way as grant. (See 76 FR 74517 (when the statute refers to an application, we use the term request) and 79 FR 64801 and 64802 (II

doi:10.1007/s10549-012-2391-z