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10.1371/journal.pone.0255822 143

In addition, genetic deletion of BMAL1 impaired Notch-inhibition-induced vascular sprouting

The reduction of BDNF not only affects neuronal health but also further exacerbates the dysregulation of neurotransmitter balance, creating a vicious cycle that can contribute to the onset of depressive symptoms (Peregud et al

Hot-water, ethanol and methanol-based extraction of mycelium were common approaches, as well as administration of lyophilized crude extracts, each of which would result in differing concentrations of erinacines administered across studies, limiting repeatability and reliability