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Adequate intake of cysteine and NAC is vital for health as they help replenish glutathione, the most potent antioxidant in the body

Other targeted HK2 inhibitors include lonidamine (LND) [88], GEN-27 [89], and some natural compounds, such as resveratrol and astragalin [90, 91]

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The reported efficacy as a maintenance therapy represents a potentially significant advance in oral drug treatment particularly if safety profiles are mirrored in routine clinical use (Table 4)

Combined with notoriety bias (the tendency for clinicians and owners to report cases that fit a publicized pattern while overlooking those that do not) and the denominator blindness inherent in a system with no defined reporting population, the shape of the FDAs DCM data is entirely consistent with a reporting artifact layered on top of a large background burden of disease