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The change of polarization can modulate the production of proinflammatory and anti-inflammatory cytokines by macrophages, thus regulating the bone-immune microenvironment and preventing alveolar bone loss (Pajarinen et al., 2019

Recent studies have found that UA may not only directly reduce oxidative stress and improve the clearance of A and -syn by inducing autophagy, but also reduce p-tau formation through Akt activation [171](Fig