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Within the TME, a variety of immunosuppressive elements, such as immunosuppressive cells, tumor cells, and inhibitory cytokines, can engage with receptors, leading to T-cell depletion

AEs leading to trial product discontinuation occurred in 2/62 (3%) participants in the CagriSema 2.4 mg/2.4 mg group, 2/63 (3%) participants in the CagriSema 1 mg/1 mg group, and 2/64 (3%) participants in the placebo group