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Administered intravenously or intramuscularly, Methotrexate requires careful dosing and monitoring to mitigate potential side effects, including liver toxicity and bone marrow suppression, ensuring safe and effective treatment

Study Design: Validating Immune Synergy in Early Relapse MAJEStec-3 is a global, randomized, open-label Phase III trial designed to test the hypothesis of immune synergy between the CD38-targeting antibody Daratumumab and the BCMA x CD3 bispecific antibody Teclistamab

Also, baseline TSH levels were higher and FT4 levels significantly lower (both indicating below optimal thyroid function) in the winter than in the summer among those who did not supplement with any vitamin D

doi: 10.1186/s40104-025-01159-z 13

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