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Patients and methods Study design The study protocol was conducted in accordance with the Declaration of Helsinki, in compliance with the International Conference on Harmonization - Good Clinical Practice and reviewed and approved by the Institutional Review Board of Faculty of Medicine, Chulalongkorn University

Numerous compounds created to influence 7nAChRs demonstrated pro-cognitive behavior in animals, and some of them have proven beneficial in preliminary clinical trials

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gingivalis can produce SCFAs through proteolysis, and the concentration of SCFAs in the gingival crevicular fluid (GCF) of periodontitis patients is positively correlated with periodontal clinical indicators (probing depth, bleeding index, attachment loss)

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