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Notably, nutrient deprivation-induced ERS also influences the tumor immune microenvironment, transmitting regulatory signals via exosomes and other carriers to suppress T-cell function and promote the polarization of immunosuppressive M2-type macrophages [24]

This sets up a vicious loop: hyperglycemia oxidative stress low GSH worse insulin resistance more hyperglycemia

Under non-stress conditions Pap1 localises to the cytoplasm by continual export from the nucleus, a process mediated by the karyopherin Crm1 and the RanGAP Hba1 (Toone et al, 1998)

Lin X, Zhan B, Wen S, Li Z, Huang H, Feng J

These people are suffering from a breakdown in the immune system called toxicant-induced loss of tolerance, or TILT