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further refined these findings, demonstrating that intravenous vitamin C significantly reduced vasopressor requirements and improved the Sequential Organ Failure Assessment (SOFA) score (Liang et al., 2023)

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By capturing molecular features such as aromaticity, hydrophobicity, charge, and hydrogen bond donor/acceptor properties, pharmacophore fingerprints enable the assessment of similarity between target binding sites, considering energy-minimized conformations of molecules to extract key pharmacophore features [101]

If folate is low, or if folate status looks acceptable while the broader picture still suggests imbalance, you can adjust the plan with far more precision