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Generation and evaluation of isogenic IPSC as a source of cell replacement therapies in patients with Kearns Sayre syndrome

Promoter sequence of phosphoenolpyruvate carboxy kinase 1 ( pck1 ) gene, was used to drive expression of a Casper3GR, which is a dual fluorescent probe that is cleaved by caspase-3, hence provides a fluorescence resonance energy transfer (FRET)-based apoptosis sensor in the liver [62]