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As alluded to above, CL is vital for mitochondrial ATP production in the respiratory chain and for preserving IMM organization [28, 80]

The expression of Nrf2 has been shown to promote SCs-mediated neurological recovery in DPN (158), whereas salvianolic acid A, paeoniflorin, and the traditional Chinese medicine Tangluoning were all found to have a modulatory effect on Nrf2 expression in SCs in the HG environment (159, 160)

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Cardiovasc Res (2012) 95(2):2519

GlyT1 inhibition increases extracellular glycine availability at synaptic sites, thereby facilitating co-agonist occupancy at NMDA receptors and modulating glutamatergic neurotransmission