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Additionally, the absence of microbiota, or the presence of broad-spectrum antibiotic-induced dysbiosis, triggered the NOD-like receptor family pyrin domain (PYD)-containing 6 (NLRP6)/Caspase 11 (Casp11) inflammasome-mediated pathway and subsequent loss of iEANs and enteric neuropathy (Muller et al., 2020a)

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Type I collagen and type II collagen are both fibrillar collagens that undergo significant changes in composition and organization as the IVD develops into a load bearing structure, which allow the IVD to withstand internal and external forces that are applied to the spine

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