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Women are more commonly affected than men and it tends to run in families

J Nutr Biochem (2011) 22:30110

Biological Sciences

Excretion into biliary canaliculi is the rate-limiting step of the entire bilirubin metabolism pathway and occurs on the canalicular membrane of the cell via a specific transporter, multidrug-resistance associated protein-2 (MRP2), which is energy (ATP) dependent

These findings suggest that melatonin supplementation may improve IVF-FET outcomes in women of advanced maternal age by modulating cuproptosis and ferroptosis pathways and enhancing mitochondrial function, potentially offering a promising adjuvant therapy for improving IVF success rates in older women