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evaluated ebselen and a collection of its derivatives as inhibitors of the PL pro , leading to identification of inhibitors with IC 50 values in the nanomolar range 38

These chemically diverse compoundsincluding ketones, aldehydes, and alcoholshave a 13-carbon backbone

The disclosure further relates to a pharmaceutical composition comprising an antibodydrug conjugate as disclosed herein, in combination with one or more pharmaceutical acceptable excipient, diluent or carrier, optionally comprising other active ingredients, for example anti-cancer drugs or immunotherapeutic drugs such as immune checkpoint inhibitors

10.1007/s00441-019-03016-8 26 HedenstiernaG.LarssonA

"Questions and answers on the use of dabigatran and perspectives on the use of other new oral anticoagulants in patients with atrial fibrillation