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Gautham Reddy 6 Christophe Corpechot 7 Susheela Carroll 8 Ke Yang 9 Daria Crittenden 8 Charles McWherter 9 , 1 Liver Institute Northwest, 2 California Pacific Medical Center, 3 Weill Cornell Medical College, New York, NY, 4 California Liver Reasearch Institiute, 5 Beth Israel Deaconess Medical Center, Boston, MA, 6 University of Chicago Medical Center, 7 Saint-Antoine Hospital, Paris, France, 8 CymaBay Therapeutics Inc, 9 CymaBay Therapeutics Background: Alkaline phosphatase (ALP) is an important marker in primary biliary cholangitis (PBC) associated with risk for disease progression