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Bu-shen-huo-xue decoction ameliorates diabetic nephropathy by inhibiting rac1/PAK1/p38MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

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These monotherapy results established proof of concept that amylin receptor agonism alone can produce clinically meaningful weight reduction and informed the dose selection of 2.4 mg for the combination product CagriSema

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Sci Rep 6:31899 Chin Y-T, Wang L-M, Hsieh M-T, Shih Y-J, Nana AW, Changou CA, Yang Y-CS, Chiu H-C, Fu E et al (2017) Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells