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6 Therapeutic strategies targeting pathophenotypes Emerging therapeutic strategies increasingly target the oxytosis / ferroptosis pathway, a promising axis for disease modification in neurodegenerative diseases including PD

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Brewer's yeast also has another alcohol dehydrogenase, ADH2, which evolved out of a duplicate version of the chromosome containing the ADH1 gene

Consequently, research has demonstrated that fisetin exhibits senolytic activity, which was discovered in a screen of flavonoid polyphenols in senescent human and murine fibroblasts (51, 52)

Quercetin application ameliorated the opacity induced by selenite treatment in an ex vivo rat lens model [84], as well as in an in vivo rat selenite cataract model [82,83]