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To reduce errors due to limited sampling in the MD simulations, the various complex systems were repeated two times with different initial velocities to perform the first 200 ns MD simulations, indicating that the root-mean-square deviation (RMSD) values of the complex backbone atoms of repeated systems were similar and fluctuated to reach a plateau after 100 ns MD simulations (Supporting Figure S2B)

Considerations for inhaled antioxidant therapies Regarding inhaled therapies, it is important to acknowledge that agents may have different effects when they are inhaled than when administered through oral or dermal routes of exposure

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Its primary function is to disrupt the interaction between FOXO4 and the tumor suppressor protein p53, leading to the selective apoptosis of senescent cells and a deceleration of biological aging