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Elevated Growth/differentiation factor 15 (GDF15) level in serum and increased GDF15 expression in cancer tissues are reported in patients with various cancers, and associated with the poor prognosis of the patients (Welsh et al., 2001

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While eicosanoids derived from EPA are less biologically active than AA-derived eicosanoids (37), supplementation with EPA and other n-3 PUFAs may nevertheless have utility in treating various inflammatory diseases

Therefore, we designed a dual ferroptosis amplification strategy using an iron-based MOFs that combined iron supply and de novo GSH elimination for effective ferroptosis management

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