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Reconstituted at 28 C, use within 14 days

Permeability in the small intestine is assessed with L-rhamnose and lactulose as per the dual sugar test, whilst in the colon this can be assessed with the non-fermented erythritol and sucralose

Mendez-Barbero N, Gutierrez-Munoz C, Blanco-Colio LM (2021) Cellular crosstalk between endothelial and smooth muscle cells in vascular wall remodeling

Glucagon-like peptide-1 (GLP-1) agonists are synthetic hormones used to lower blood sugar and reduce appetite

Collectively, these enzyme-reactive Pro-PROTAC designs underscore the versatility of leveraging endogenous tumor characteristics to govern PROTAC function, offering a robust framework for advancing TPD therapeutics