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An early trial in 160 men and women diagnosed with a recent MI showed that oral L-carnitine (4 g/day) in addition to standard pharmacological treatment for one year significantly reduced mortality and the occurrence of angina attacks compared to the control (47)

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These intermediates are activated by the CYP450 enzyme system present in the liver and bladder epithelial cells, leading to substantial ROS production (Bruckner et al., 1989