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Design of a Janus kinase 3 (JAK3) specific inhibitor 1-((2 S ,5R)-5-((7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans