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Ferroptosis is biochemically characterized by the generation of ROS and iron overloading

Additionally, its dual benefits in managing blood sugar and improving overall metabolic health add to its appeal

These immunogenic properties are particularly significant in glioblastoma, where ferroptosis-related gene signatures demonstrate strong predictive value for response to PD-1 blockade in recurrent tumors, suggesting an intrinsic synergy between ferroptosis and immune checkpoint inhibition [129]

Cosmetic ingredient approval is regulatorily distinct from drug approval

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